Lumbar 5-sacral 1 pain can’t stand and can’t sit, consider lumbar spondylolisthesis, interspinous ligament strain, lumbar disc herniation, according to the cause of the disease for drug treatment, physical therapy or surgical treatment. 1. Lumbar spondylolisthesis: pain caused by sudden change of posture and limitation of lumbar spine activities can be repositioned by massage, and the pain will be relieved immediately. Bed rest for 3~5 days. 2. Interspinous ligament strain: manifested as pain along the spinous process, specific parts of the pain. To reduce bending movements, you can take oral non-steroidal anti-inflammatory drugs, such as nimesulide dispersible tablets or diclofenac sodium enteric-coated tablets, local closed injection therapy, ultrashort wave physiotherapy. 3. Lumbar disc herniation: lumbar traction can be performed to reduce the pressure on the lumbar intervertebral space, and the pain can be relieved after the nerve compression is reduced. Conservative treatment is ineffective, and intervertebral foramenoscopy surgery can be considered. Lumbar 5-sacral 1 pain symptoms if the persistence of non-relief, need to go to the hospital orthopedic examination, to identify the specific causes of further treatment.