Hepatitis B patients taking interferon may lead to elevated blood sugar. Hepatitis B patients in the use of interferon treatment process, may cause abnormal elevation of blood glucose, with interferon for the body’s immune function of the impact of interferon, will lead to the thyroid function and pancreatic islet function is affected, resulting in the body’s glucose metabolism disorders, caused by the blood sugar increase. Clinically, if patients need to use interferon, they usually need to take glucose-lowering drugs, such as metformin or gliquidone; inject insulin, such as insulin injection and insulin glargine to control blood glucose, and only when the blood glucose level is normal can interferon be used, and at the same time, in the process of using it, it is necessary to monitor blood glucose. Common adverse effects of interferon include fever, myalgia, fatigue and headache, etc. It should be noted that interferon allergy is prohibited, and it is necessary to be careful with sleeping pills or sedatives when using interferon. In addition, the application of interferon has certain risks, patients need to get the guidance of a specialist.