Feeling uncomfortable when thinking of a certain part of the body may be a normal physiological reaction, but it may also be caused by pathological factors such as autonomic dysfunction and hysteria. 1. Physiological reaction: such as excessive concern for a certain part of the body, or excessive concern for a certain thing, there is the thought of a certain part of the body, feel uncomfortable performance. 2. Pathological factors (1) Autonomic dysfunction: usually related to excessive psychological pressure, anxiety, irritability, etc. When the autonomic nervous system is stimulated, it will involve multiple systems, including the cardiovascular and respiratory systems, so it will suddenly feel uncomfortable when thinking of a certain part of the body, which usually may be accompanied by forgetfulness, numbness of the limbs, diarrhea, vomiting and other symptoms. (2) Hysteria: It is a kind of mental disorder, when the emotion is too irritable, it may send out signals in the body, thus causing feeling uncomfortable when thinking of a certain part of the body. Thinking of a part of the body feels uncomfortable, in addition to the above factors, may also be due to anxiety, depression, obsessive-compulsive disorder, such as symptoms persist for a long time, it is recommended to consult a doctor in a timely manner, improve the relevant examination, to clarify the cause of the disease and be targeted treatment.