Advanced gallbladder cancer may be comatose before dying. Before dying, patients with advanced gallbladder cancer firstly show progressive aggravation of jaundice, which starts with dark yellow skin, soybean oil urine color, white or clay-like stool. With the aggravation of jaundice, the skin can appear atrophic yellow color or yellowish green, accompanied by severe itching of the skin all over the body. Persistent jaundice can lead to serious liver function disorder and even liver failure, which can lead to patient’s unconsciousness, lethargy, coma and other manifestations until death. Secondly, patients with advanced gallbladder cancer can have multiple metastases, mostly to liver, and the massive destruction of liver cells may lead to hepatic encephalopathy, which will show symptoms of unconsciousness, behavioral disorder, drowsiness and coma. Therefore, coma may appear before death in advanced stage of gallbladder cancer, so when suspicious symptoms are found, patients should consult doctor in time and take certain measures in order to improve the survival period of patients.