Hand, foot and mouth disease is an acute infectious disease caused by enterovirus, which is mainly transmitted by fecal-oral route, followed by respiratory secretions and close contact. Patients and carriers of the virus stool, respiratory secretions (such as sputum), contact with their contaminated clothing and daily necessities can be transmitted, highly contagious, contaminated hands are most likely to be ignored, but is the key part of the transmission. Hand, foot and mouth population is generally susceptible to the disease, but it mostly occurs in children under 5 years old (especially under 3 years old), this stage of the child resistance and immunity are relatively weak, need to be taken care of by parents, and it is easy to cause intra-family transmission. Therefore, if someone in a family is found to have HFMD, it is best to live separately from the baby. Newborns with HFMD should be seen as soon as possible to avoid delayed treatment and serious consequences.