Hepatitis B 4-5 positive may be in the recovery period of infection after infection with hepatitis B, which is self-healing; or it may be caused by the mutation of the virus, which belongs to hepatitis B infected people. Hepatitis B 4-5 positive refers to positive hepatitis B E antibody and hepatitis B core antibody. Most of these cases are due to the fact that after being infected with hepatitis B, the body relies on its own immunity to clear the virus, and it is still in the recovery period of the infection, and has not yet produced antibodies. In this case, the infection of hepatitis B is self-healed, and the body will produce protective antibodies. In rare cases, hepatitis B 4.5 positivity is caused by mutation of the hepatitis B virus, due to the mutation of the hepatitis B virus, the surface antigen of hepatitis B can be negative. In this case perfecting the Hepatitis B viral load test can detect the Hepatitis B virus, indicating that the person tested is infected with Hepatitis B. Hepatitis B IV-V positive requires further consultation in the Liver Disease Clinic.