The rise of CA199 is mainly due to overproduction, biliary obstruction, cell destruction and other reasons. 1. Excessive production: it is mainly due to various malignant tumors, which will cause obvious increase of corresponding antigen production, the most common ones are pancreatic cancer and bile duct cancer. 2. Biliary obstruction: when there is biliary obstruction, the antigen generated by cells will enter the blood in large quantities because of obstruction, causing the corresponding indexes to rise, and the common reasons are common choledocholithiasis and so on. 3. Cell destruction: cell damage caused by various reasons will cause a large amount of antigens normally present in the cells to be released into the blood, common causes include cirrhosis of the liver and pancreatitis. Some lesions cause CA199 to rise, which is caused by a combination of reasons, clinically, once you find obvious abdominal pain, jaundice and abdominal masses, you need to consult a doctor in time to observe the cause of the cause of the disease through a comprehensive judgment of the examination, under the guidance of the clinician to carry out standardized treatment.