When a pregnant woman is infected with the herpes simplex virus, she can be treated with the herpes simplex vaccine or cytarabine if she has not reached her due date. If it is late in pregnancy, cesarean section should be used. Herpes simplex virus infection in pregnant women can be transmitted to the fetus via the placenta and to the newborn during delivery if infection occurs in the birth canal. When herpes simplex virus infection is complicated in early pregnancy, it can be transmitted through the placenta and the reproductive system, causing intrauterine infections in the fetus and leading to the development of malformations, such as malformations, retinal hypoplasia, and cerebral calcifications. Early rupture of membranes and preterm labor can occur easily in late pregnancy with herpes simplex virus infection. If herpes simplex virus infection is suspected, cervical mucus should be obtained for viral culture and serologic testing prior to delivery. Herpes simplex vaccine or cytarabine can be used for treatment, and the fetus should be delivered by cesarean section in late pregnancy. The use of specific medications should be in accordance with the doctor’s instructions. It is recommended that patients do not judge or diagnose on their own based on one result, but should consult a doctor in time, who will analyze the situation comprehensively, make a clear diagnosis, and give targeted treatment.