Chronic renal failure usually presents with morning sickness, a common symptom of the digestive system. Chronic renal failure is a common outcome of various chronic kidney diseases that continue to progress to advanced stages. It is a clinical syndrome characterized by metabolite retention, imbalances in water, electrolyte, and acid-base balance, and systemic symptoms. Gastrointestinal digestive system symptoms are usually the earliest manifestation of chronic renal failure, mainly manifested by lack of appetite, nausea, vomiting, and urine odor in the mouth, mostly due to the nitrogen metabolites can not be discharged after renal failure, and the gastrointestinal tract is stimulated by decomposition. In severe cases, erosion and ulceration of gastric mucosa can occur, and gastrointestinal bleeding occurs. Chronic renal failure patients with morning sickness, it is recommended to go to the hospital in a timely manner, under the guidance of a professional physician to improve the examination and develop a treatment plan.