Barringly, commonly referred to clinically as Guillain-Barré syndrome and Guillain-Barré syndrome, Guillain-Barré syndrome may present with respiratory muscle weakness, leading to respiratory distress, which may be life-threatening. Guillain-Barré syndrome can present as flaccid limb muscle weakness. In most patients, the muscle weakness progresses from the lower to the upper extremities and gets progressively worse over several days. Some patients have varying degrees of neuromotor dysfunction in the brain, with muscle weakness in the face or medulla oblongata being common and may be seen as the first symptom. In a few patients, this may be accompanied by difficulty in opening the mouth, inadequate and weak tongue extension, and paralysis of the extraocular muscles. In severe cases, weakness of the neck and respiratory muscles occurs, leading to dyspnea. Dyspnea is severe enough to cause respiratory failure, which can be life-threatening. Patients with dyspnea and paralysis of medulla oblongata innervating muscles should pay attention to keep the airway open, especially pay attention to strengthening sputum suction and preventing aspiration. For patients with rapid progression of the disease, accompanied by respiratory muscle involvement, the condition should be closely observed, if there is obvious dyspnea, lung capacity significantly reduced, the partial pressure of blood oxygen significantly reduced, should be carried out as soon as possible endotracheal intubation or tracheotomy, mechanically assisted ventilation and so on. When the above symptoms occur, early medical attention is recommended.