Booster shots currently refer to the New Crown Vaccine Booster Shot, and it is recommended to seek prompt medical attention for treatment of a particularly large reaction after a booster shot. Vaccination generally includes local reactions and systemic reactions, which need to be dealt with according to the specific situation. 1. Local reaction: after vaccination, redness, swelling, pain and hard nodules may appear at the site of vaccination, which can generally subside in 2~3 days; in this case, it can also be relieved by hot compresses, such as using a towel, soaking in hot water and then applying hot compresses on the site of vaccination, which can relieve the discomfort by promoting blood circulation. 2. Systemic reaction: may cause fever, tiredness, fatigue and other symptoms; at this time, need to pay attention to keep warm, drink more warm water; fever can also be dealt with through physical cooling therapy, such as ice packs on the forehead, etc.; if the body temperature is more than 38.5 degrees, you can also take antipyretic medications under the guidance of a physician, such as ibuprofen and acetaminophen tablets. 3. If anaphylaxis, laryngeal edema, localized anaphylactic necrotic reaction and other serious allergic reactions occur, it is necessary to consult a doctor in time for symptomatic treatment. In addition, there are certain contraindications to vaccination, in order to avoid affecting health, it is recommended that the vaccinee needs to consult a specialist before vaccination, and should not blindly use medication on their own.