Stomach discomfort after overeating may be caused by gastritis, indigestion, etc. It can be relieved the next day by dietary adjustments, medication such as domperidone and omeprazole, and treatment of the original disease. 1. General treatment: Fasting for the time being, or only eating light, easy-to-digest food, so that the gastrointestinal tract can fully rest. 2. Medication: (1) Gastrointestinal power drugs: gastrointestinal power drugs such as domperidone and mosapride can be applied to promote gastrointestinal peristalsis. (2) Acid inhibitors: Omeprazole and cimetidine can be used to inhibit gastric acid secretion. (3) Gastric mucous membrane protector: gastric mucous membrane protector such as bismuth potassium citrate can be applied to relieve the discomfort. (4) Digestive enzyme preparations: Multi-enzyme tablets and compound digestive enzyme capsules can be taken orally to help digestion. (3) Treatment of primary disease: Overeating may cause the attack and aggravation of the patient’s underlying disease, and may even cause other diseases, such as perforated peptic ulcer, pancreatitis, cholecystitis, intestinal obstruction, digestive system infections, etc., which need to be dealt with through gastrointestinal decompression, anti-infection, surgery, etc., before the symptomatic treatment. After overeating stomach discomfort is recommended to consult a doctor in a timely manner, under the guidance of the doctor to specify the cause of the standardized treatment, to avoid adverse consequences.