During the treatment of lumbar spine tuberculosis, if the anti-tuberculosis drugs cause damage to the liver and kidney function, the condition is serious enough to stop the drugs and change the drugs under the guidance of the doctor, and the mild patients add drugs to protect the liver and kidney. At the same time, close observation and review, dynamic adjustment. 1. Adjust the drug dose or stop the drug: as most of the anti-tuberculosis drugs (such as isoniazid) are excreted through the liver and kidney, which may cause damage to the liver and kidney function, such as fatigue, loss of appetite, nausea, jaundice, etc., patients should go to the hospital in time to make drug adjustments; drugs that have a greater impact on the liver and kidney damage should be reduced in dosage or discontinued after the doctor’s assessment, to avoid aggravating the damage to the liver and kidney. 2. Drugs to protect liver and kidney: such as magnesium isoglycyrrhizinate, diammonium glycyrrhizinate, urotoxin clear granules, huangkui capsule, etc., to improve liver function abnormality, to reduce ghrelin and ghrelin aminotransferase, to reduce the elevation of urinary protein and creatinine, so as to improve the function of liver and kidney. During the treatment, to maintain a positive mindset, patients with medication need to be under the guidance of a doctor, at the same time to closely observe their own symptoms, timely review, timely medical treatment, so as not to cause more serious consequences.