Abnormally elevated blood creatinine in men, even above the normal value, suggests impaired kidney function, and the specific time of progression to uremia varies from person to person and cannot be generalized. Creatinine is a metabolic waste of the human body, mainly produced by muscle tissue metabolism, 99% of creatinine is excreted through the kidneys, so the level of creatinine reflects the kidney function to a certain extent. When the blood creatinine value exceeds 707μmoI/L, it is clinically defined as the uremic stage. In men, blood creatinine 110 μmol/L belongs to the high limit state of normal value, which indicates normal renal function, but there are individual differences, so the dynamics need to be observed clinically. The time of its progression to uremia is related to the type of disease, treatment and the patient’s own constitution, and may vary from 1 to 20 years, and the exact time cannot be specified. Patients with blood creatinine 110μmol/L are recommended to visit the nephrology department of regular hospital in time to receive standardized treatment of Chinese and Western medicine. Renal function should be rechecked every 3 months, and urological ultrasound may be performed if necessary. If the blood creatinine value is stable, there is no need to worry too much.