Urine protein is a common symptom of chronic kidney disease, the more proteinuria plus indicates the more serious the disease, not uremia. Uremia is the final end of all chronic kidney diseases, is based on glomerular filtration function as a judgment, when the blood creatinine reaches 707μmol/L is to the stage of uremia. While urine protein (++++) can only indicate that the kidney disease is more serious, but it is not certain that it is to uremic syndrome. Chronic kidney disease developed to uremia, all systems of the body are damaged, as water, sodium and metabolites can not be effectively excreted, visible edema of the limbs, urine volume significantly reduced, persistent hypertension, and the severity of urine protein, does not directly reflect the glomerular filtration function, so urine protein (++++) can not prove that is uremia, urine protein (++++) can take Captopril, Huangkui capsule.