Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia, in turn, is caused by defective insulin secretion or impairment of its biological action, or both. The long-term presence of hyperglycemia in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. So what conditions in daily life can lead to diabetes? Here’s a quick look with the family doctor online. What are the causes of diabetes 1. Genetic factors There is significant genetic heterogeneity in either type 1 or type 2 diabetes. There is a tendency for diabetes to develop in families, and 1/4 to 1/2 of patients have a family history of diabetes. There are at least 60 clinical genetic syndromes that can be associated with diabetes. type 1 diabetes has multiple DNA loci involved in the pathogenesis, with the DQ locus polymorphism in the HLA antigen gene being the most closely related. In type 2 diabetes a variety of clear genetic mutations have been identified, such as insulin genes, insulin receptor genes, glucokinase genes, mitochondrial genes, etc. 2.Environmental factors Obesity due to excessive eating and reduced physical activity is the most important environmental factor for type 2 diabetes, making individuals with genetic susceptibility to type 2 diabetes susceptible to the disease. type 1 diabetes patients have abnormal immune system, which leads to autoimmune reaction after certain viruses such as coxsackie virus, rubella virus, mumps virus, etc. infection, which destroys insulin beta cells. The source of diabetes in daily life 1, overeating overeating susceptible to diabetes, if people overeat, the liver “sterol regulatory element binding protein 1C” (referred to as SREBP-1C) will increase, resulting in a decline in insulin action, which in turn leads to diabetes. Long-term overeating will make the body’s insulin-secreting pancreatic B cells in the long-term “burden” overload, relative fatigue, resulting in insulin secretion dysfunction, especially in people with genetic susceptibility to diabetes, is very likely to trigger diabetes. In addition, long-term over-eating diet for obesity, hypertension, hyperlipidemia, hyperuricemia and other people with insulin resistance factors, more likely to cause excessive accumulation of insulin in the body, resulting in hyperinsulinemia, which is the main cause of systemic atherosclerosis. 2, fruit as a meal When the day is hot, even if the delicious meal in front of you, it is not easy to cause appetite, some people will be fruit and drinks as the main food, often with watermelon, peaches and other large piles of fruit to cope with a meal. Doctors say that all kinds of fruits and drinks, a large part of the fruits and drinks contain high sugar, for some of the original blood sugar is high in middle-aged people, uncontrolled eating is often easy to make the blood sugar rise, thus triggering diabetes. 3, bad sleep People who sleep badly or too little are prone to diabetes. Swedish researchers in the 8,000 middle-aged Swedes without a history of diabetes followed up to 10 years later found that more than 500 of these people have unknowingly suffered from varying degrees of mild diabetes, and these people have a common cause of the disease is bad sleep or too little sleep. 4, a can of sweet soda a day Women drink more than a can of sweet soda a day, not only easy to become obese, but also increased the chances of diabetes. Those women who drink at least one can of sweet drinks a day have an 85% higher risk of developing type II diabetes than those who drink less. In addition to the excessive calories contained in soft drinks, the rapid absorption of many sugars by drinkers also makes them prone to obesity and diabetes. This may not be a sugar problem, but has to do with the fact that sugar is in liquid foods. So soda pop and other drinks that provide energy may lead to excessive energy intake, and finally cause overweight and obesity. 5, too much iron in women Too much iron stored in the body can lead to women developing adult-onset diabetes, so early blood tests are likely to help identify people at risk of the disease. Ferritin is a blood iron and protein complex, is a sign of iron accumulation. Researchers found that even after taking into account factors such as obesity and other risk factors, including family history of diabetes, physical activity, alcohol consumption and diet, women with higher levels of ferritin at the beginning of the study were at nearly twice the risk of developing diabetes.