Negative urobilinogen indicates the possibility of obstructive jaundice. Urobilinogen is the body’s binding bilirubin excretion to the intestinal tract after the conversion into urobilinogen, urobilinogen through the absorption into the blood, with the urine excretion and detected. Under normal circumstances, urobilinogen is present in the urine, so the test is weakly positive for urobilinogen. However, if urobilinogen is negative, it is likely that bilirubin is blocked from being excreted from the liver or gallbladder into the intestines, a condition known as obstructive jaundice. This condition is called obstructive jaundice. It can be caused by stones in the common bile duct, cancer of the pancreatic head, and tumors of the duodenal papilla. These patients will also show more obvious symptoms of jaundice, with a yellow coloration of the eyes and skin. Therefore, if the urine is negative for bile and the skin is yellow, an ultrasound or CT scan of the liver, gallbladder, and pancreas should be performed in a timely manner.