Urobilinogen is one of the routine urine tests, and in normal people it is negative or weakly positive. Therefore, low urobilinogen can be seen in normal people, but also may be caused by disease. However, it is not possible to determine whether there is a clinical disease and the specific type of disease based on urobilinogen alone. A combination of symptoms, signs, medical history, and examination should be used to further define the condition. Obstructive biliary tract disease is more likely to result in a decreased quantitative urobilinogen level or a negative qualitative urobilinogen level. Urinary bilirubin is also negative. The liver function of total bilirubin, direct bilirubin, indirect bilirubin, glutamyl transpeptidase, alkaline phosphatase and other related indicators, there will also be a significant increase. Different surgical or interventional treatment options are also needed depending on the specific cause of the biliary obstruction. In the normal population, weakly positive or negative urobilinogen does not require any clinical treatment.