Thyroglobulin antibodies 500IU/ml are elevated and abnormal. High thyroglobulin antibodies indicate autoimmune inflammation of the thyroid gland, such as Hashimoto’s thyroiditis. 1. Elevated thyroglobulin antibodies indicate autoimmune damage to the thyroid gland, which is common in Hashimoto’s thyroiditis, also known as chronic lymphocytic thyroiditis. If accompanied by hyperthyroidism or hypothyroidism, you need to use antithyroid medication or thyroid hormone therapy under the guidance of a doctor. 2. If the thyroglobulin antibody is only 500IU/ml and the thyroid function is normal, there is no need for treatment for the time being, and regular checkups of the thyroid function can be done. Elevated thyroglobulin antibodies should be treated under doctor’s supervision.