High pressure of 180 mmHg and low pressure of 100 mmHg is a grade 3 hypertensive disease, often combined with risk factors including target organ damage, diabetes mellitus, and clinical coexisting diseases, so it is a very dangerous state. Its 10-year cardiovascular and cerebrovascular event rate is as high as 20%-30%, or even more than 30%. It needs to be given therapeutic lifestyle improvement, 24-hour smooth antihypertensive medication, and active inquiry for any target organ function or organism-related damage, and give corresponding medication or surgery treatment. High pressure of 180 mmHg and low pressure of 100 mmHg are often serious, and if neglected often result in complications as follows: 1. cardiac complications, including angina pectoris, myocardial infarction, heart failure. 2. cerebrovascular complications, such as hemorrhagic stroke, ischemic stroke, hypertensive encephalopathy. 3. renal complications, such as chronic renal insufficiency. 4. fundus complications, including retinal lesions, fundus changes, etc.