Red spots on the glans may be caused by pearly penile papules, glansitis, syphilis, etc. Patients are advised to be treated by medication, surgery and physical methods. 1. Pearly penile papules: its etiology is unknown, characterized by the appearance of pearly, translucent red or yellow papules on the coronal edge of the penis and the coronal sulcus as a skin disease. It is a normal phenomenon and does not require special treatment. If you feel uncomfortable, you can also use liquid nitrogen cryotherapy, low temperature can make the epidermal cells at the lesion damaged, edema, necrosis, shedding to achieve the therapeutic effect. 2. glans inflammation: inflammation occurring in the mucosa of the glans, can be caused by infection, local irritation and many other different reasons. The patient’s foreskin and prepuce and glans appear red, swollen, painful, itchy discomfort. Antibiotics can be selected according to the results of drug sensitivity for treatment, such as gentamicin, erythromycin, metronidazole and so on. 3. Syphilis: it is a chronic sexually transmitted disease caused by syphilis spirochetes that invades multiple systems. The first manifestation is a small red spot on the external genitalia, which can leave a dark red scar or a discoloration of the skin here and other symptoms. Penicillin is the drug of choice for the treatment of syphilis, penicillin allergy, doctors usually choose ceftriaxone sodium, etc. as an alternative drug. In addition, red spots on the glans can also be seen in other diseases, it is recommended that patients go to the hospital in time to do the relevant examination, follow the doctor’s instructions for treatment, to avoid delaying the condition. The above drugs need to be used under the guidance of a professional physician, to avoid blind use of drugs, so as not to aggravate the condition.