Tuberculosis medication taken with generalized weakness requires prompt medical attention, liver and kidney function tests, and adjustment of the treatment plan according to the specific situation. On the one hand, tuberculosis itself may cause the body to have symptoms of generalized weakness, therefore, when taking tuberculosis drugs and undergoing anti-tuberculosis treatment, generalized weakness is not necessarily caused by the drugs. Tuberculosis patients should pay attention to strengthening nutrition, appropriately increase the intake of high-calorie, high-protein, high-vitamin food. Regular life, do not stay up late, ensure more than eight hours of sleep every day. However, if the generalized fatigue persists and worsens while taking anti-tuberculosis drugs, it may be caused by tuberculosis drugs. At this time, it is recommended to carry out liver and kidney function tests in a timely manner and communicate with the treating doctor to consider adjusting the drug dosage or replacing or stopping the drugs.