It is possible that severe hair fall is related to deficiencies of trace elements such as zinc, iron, and vitamins. Zinc can be involved in influencing cell division, growth and regeneration. Zinc deficiency can cause the epidermis to become hyperkeratotic and easily flaky, and dermatitis and hair loss can occur. Zinc deficiency can also promote apoptosis, which can lead to the hair follicle’s growth phase shifting to the regression phase and then to the resting phase causing clinical hair loss. Iron deficiency inhibits hepatic synthesis of DNA and decreases protein synthesis and utilization, which in turn leads to a decrease in nutrients at the hair follicle and hinders hair growth. In addition, iron deficiency anemia, which is caused by iron deficiency, can also cause hair growth to be affected by lack of oxygen. Sometimes hair loss may even be the only symptom of anemia. In addition the biosynthesis and energy metabolism of hair follicles may be related to vitamins. Vitamin deficiencies can lead to hair changes, shedding of hair at the end of growth, dry, straggly hairs, and lighter color. In addition, the quantity and quality of hair growth is also related to the individual’s nutritional status, lifestyle, genetics, immunity and other issues, and can also be related to the acquired environment. Severe hair loss requires prompt medical attention and treatment.
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