The powerful sperm production function of the testicles is fully prepared for the birth of offspring, but this does not mean that it is possible to have an unrestrained sex life, too frequent sex has many harmful effects, one of which is that it can lead to male infertility. The number of sexual intercourse too often can lead to each semen contains too few sperm or sperm most in the infantile and immature stage, sperm vitality is poor; plus too much too frequent sexual stimulation can make the epididymal gonadal organs in a long-term congested state, resulting in glandular secretion disorders, affecting the semen composition and acidity, thus causing adverse effects on fertility, and in serious cases can lead to infertility. In addition, too frequent sexual intercourse makes the wife frequent repeated exposure to the husband’s sperm, semen, for some women who can produce a specific immune response, these sperm, semen is an antigenic material, easy to stimulate the body to produce anti-sperm antibodies. The more frequent the sexual intercourse, the more the woman absorbs the man’s semen, the more the antigen excites the antibodies, thus leading to the occurrence of immune infertility.