Adult renal pelvic separation of 35mm is more serious, belongs to the symptoms of severe hydronephrosis, the treatment needs to drain the urine, at the same time remove the cause of the disease, release the obstruction, pay attention to the prevention and treatment of complications. Clinical separation of the renal pelvis greater than 14mm refers to the manifestation of severe hydronephrosis. Prolonged severe hydronephrosis may lead to the damage of renal function, and this situation is considered more serious. It is recommended that patients first drain the urine to protect the kidney, mainly including internal drainage and nephrostomy. For those who have urinary stones, they can take oral tamsulosin and other medications as prescribed by the doctor, and minimally invasive surgical treatments such as extracorporeal shock wave lithotripsy can be performed when the stones are large. In the case of hydronephrosis caused by obstruction such as compression and spread of advanced tumors, it is recommended to place a double J tube through cystoscopy for long-term internal drainage of renal pelvic urine. In case of serious infection, antibiotic therapy such as ofloxacin should be given as prescribed by doctor. Adult renal pelvis separation 35mm is more serious, it is recommended that patients go to regular hospitals for timely examination and treatment to avoid deterioration of the condition.