Tossing and turning at night may be the result of somatic discomfort, mostly due to organic lesions. For example, tumor patients can cause cancer pain, which causes sleep disturbance to patients. The main treatment is pain relief and active treatment of tumor at the same time. Tumor patients cause pain, apply pindostatin, prednisolone, and if necessary, morphine for antiemetic and analgesic treatment. Tossing and turning at night may also be a sleep disorder, which is seen in patients with neurasthenia and anxiety disorders. Neurosis can be seen in patients of any age and is mainly characterized by sleep disorders, which can present difficulties in falling asleep. There can also be sleep always early awakening and more dreaming during sleep affecting the quality of sleep. Drugs as long as the benzodiazepines, Synthroid, Zopiclone, etc.. If the patient has anxiety, depression, irritability, panic, fear and also difficulty in falling asleep, oral anti-anxiety and depression related drugs can be taken.