Fever does not usually lead directly to elevated total bilirubin, but fever caused by some diseases can lead to elevated total bilirubin.
Elevated unconjugated bilirubin and elevated conjugated bilirubin can both lead to elevated total bilirubin. Elevated unconjugated bilirubin is most often seen as a result of increased red blood cell destruction, elevated conjugated bilirubin is most often seen as a result of biliary obstruction, and elevated both are seen as a result of hepatocellular injury. Usually, low or moderate fever does not cause damage to red blood cells or hepatocytes, and total bilirubin is not elevated.
In the case of hepatitis, acute erythrocytic hemolysis, suppurative cholecystitis, cholangitis, and other diseases that can lead to fever, there is also an elevation of bilirubin, which can be relatively large.
In addition, prolonged fever can indirectly damage liver cells, and when hepatocellular damage occurs, total bilirubin will be elevated, and bilirubin elevation due to this cause is not obvious.
Once a fever with jaundice occurs, it is usually a sign of a more serious disease, and should be hospitalized in time for examination and treatment.