Creatinine 121umol/L suggests that blood creatinine is elevated, which is divided into physiological and pathological conditions. Physiological cases are seen after strenuous exercise, consuming a lot of meat, etc., which are usually not very serious; pathological cases include diabetic nephropathy, chronic kidney disease, etc., which are usually more serious and need timely treatment. Physiological: creatinine may rise transiently after strenuous exercise or consuming a lot of meat, which is usually not very serious and may return to normal after rest and diet control. Pathologic: These cases are more serious, including diabetic nephropathy and chronic kidney disease. Diabetic nephropathy is one of the major complications of diabetes mellitus, and the treatment of diabetic nephropathy includes active control of hyperglycemia, control of blood pressure, correction of lipid metabolism disorders, treatment of obesity, smoking cessation, and other measures to prevent further renal damage. Blood creatinine elevation caused by chronic kidney disease is more serious, treatment to prevent the deterioration of renal function as the main purpose, early need to clarify the cause of the disease, timely diagnosis and treatment. Patients with blood creatinine 121umol/L should go to the hospital in time, and under the guidance of professional physicians to clarify the cause of the disease and timely treatment.