Penicillin injection is not in conflict with Neocoronavirus vaccination, but the reason for the injection of penicillin needs to be clarified. If the patient is in an exacerbation of the disease which is a contraindication to Neocoronavirus vaccination, it is not recommended to be vaccinated. If the patient’s condition is under stable control and there is no physical discomfort, vaccination can be considered. Penicillin, as a commonly used clinical antibacterial drug, is often used in the treatment of pneumonia, meningitis and so on. New Crown vaccine is a virus inactivated bacterial vaccine, penicillin has no killing effect on it. It does not affect the immunization effect of the vaccine. New Crown vaccination is not recommended for acute stage disease or uncontrolled chronic disease for the time being. It is recommended to wait until the condition is stabilized before vaccination. If the patient’s condition has improved and there is no other obvious physical discomfort, vaccination can be considered. Normally, it is recommended to consider vaccination after the condition has stabilized. If necessary, the patient can go to a regular hospital for consultation and evaluation by a medical professional.