Red bumps on the inner thighs that are not accompanied by itching require careful observation of the appearance of the red bumps. If they are unilaterally distributed, have a distinct bump to the touch, and are accompanied by significant pain when pressed, it may be a bacterial infection followed by folliculitis, which can turn into a boil after a serious condition. If left untreated, it can expand rapidly and is detrimental to human health. It is recommended to take oral minocycline or amoxicillin, followed by topical mupirocin cream for a comprehensive treatment. If the inner thigh bumps show keratotic hyperplasia-like changes, it may be chronic keratotic dermatitis. The condition is formed after gradual thickening of the skin, and it is recommended to choose compound lactic acid cream with fluticasone propionate cream for treatment, which is still effective. If it is accompanied by strong pain and small visible blisters on top of the red bumps, it is considered possible that it is herpes zoster and antiviral treatment is recommended.