Metoprolol is a beta-blocker that has the effect of relieving sympathetic tension and can be taken in small amounts by patients with poor psychological profile and rapid basal heart rate. However, there is no evidence to confirm that it has a definite anxiolytic effect. On the contrary, among the adverse drug reactions, very few patients can cause depressive episodes due to long-term use of metoprolol, or the already existing depressive symptoms will be aggravated, and some patients’ original anxiety symptoms will be aggravated, so metoprolol does not have a definite anxiolytic effect. For patients with depressive or anxiety states, Metoprolol must be taken with caution, and after taking it, the psychological condition should be closely observed and psychological assessment should be done regularly to decide whether to stop or reduce Metoprolol.