The low ratio of albumin to globulin, the first thing to do in this case is to clarify the specific cause of the disease, in order to target treatment, as follows: 1, if there is a nephrotic syndrome, diabetic nephropathy and other diseases, a large amount of albumin will be lost through the urine, the albumin in the blood will be significantly reduced, the ratio of albumin to globulin will also be low, in the treatment of the main choice of drugs to protect the kidneys and reduce urine protein, such as 2, may also be due to blood system diseases, such as multiple myeloma, the body will abnormally clone a lot of immunoglobulin, the ratio of albumin to globulin will also be reduced, need to further check the bone marrow aspiration, bone marrow biopsy and other items to clarify the condition, targeted drug treatment.