Whether primary liver cancer can live more than 5 years is generally judged according to the early or late discovery of the disease as well as the stage of liver cancer, combined with the specific condition of the patient. In small hepatocellular carcinoma, if the patient’s basic condition is still good and there is no some life-threatening chronic disease, after regular treatment, it should not be a problem to live for 5 years. In advanced liver cancer, if there is already ascites metastasis, especially distant metastasis, even after comprehensive treatment and targeted therapy, there is basically no one who can live more than 5 years. On the other hand, if mid-stage liver cancer is found in time without distant metastasis, and even after preoperative interventional therapy and then surgery, combined with targeted therapy, some patients can live more than 5 years.