Ankylosing spondylitis has no relevant data to show that there is a pain stage, which is mainly divided into early and late stages, and can be treated by general treatment, drugs (diclofenac, methotrexate, etc.), surgery and other methods. 1. General treatment: regular exercise should be carried out in life, especially for thorax, spine, hip joint activities and other exercises are more effective, late-stage patients need to sit, stand and lie down in a correct posture, avoid excessive weight bearing and strenuous exercise. 2. Drug therapy: non-steroidal anti-inflammatory drugs can be used as prescribed by the doctor, commonly used drugs are diclofenac sodium, naproxen, etc., which have the effect of pain relief, and can also use sulfasalazine, etc., which is more suitable for patients with mild conditions; tumor necrosis factor TNF-alpha antagonists can also be used as prescribed by the doctor, and the commonly used drugs are infliximab, adalimumab and so on. 3. Surgery: Ankylosing spondylitis can be treated by surgery, and common surgical methods include total hip replacement, single-segment spinal osteotomy, multi-segment spinal osteotomy, single-segment spinal osteotomy plus intervertebral implantation, etc. Patients are advised to go to a regular rheumatology hospital in time. It is recommended that patients go to the rheumatology and immunology department of the regular hospital in time, under the diagnosis of the doctor, according to the specific condition of the patient, targeted treatment, so as not to cause adverse effects on the body.