Congenital intestinal atresia is not uncommon in gastrointestinal malformations and is a common cause of intestinal obstruction during the neonatal period, accounting for 24% to 32%. 1 case can occur in 1500 to 2000 cases of newborns, more males than females, mostly in premature infants. Atresia can occur in any part of the intestinal canal, with the ileum being the most common, accounting for about 50%, followed by the duodenum, accounting for about 25%, the jejunum less common, and the colon rare. I. Etiology Due to incomplete cavitation during embryonic development. It is also thought to be due to impaired blood circulation in the fetal intestine, which prevents its normal development. There are three general types of intestinal atresia: 1. The presence of a septum in the intestinal lumen, which completely obstructs the intestinal lumen. 2. The intestinal canal is interrupted and the two intestinal segments are connected only by a cord-like fibrous band. 3, intestinal atresia is completely interrupted at both ends of the blind pouch, intestinal mesentery also has a “v” shaped defect, single atresia is more, there can also be multiple atresia, as if a series of sausage shape. Regardless of the level of intestinal atresia, it is a complete intestinal obstruction, the main manifestations are: 1. vomiting In children with high atresia, vomiting occurs after the first feeding after birth, gradually increasing and frequent, vomit contains water, milk and bile from feeding, while in ileal and colonic atresia, vomiting occurs 2-3 days after birth, vomit contains bile and fecal juice, and the number of vomiting is not as frequent as in high atresia. 2, abdominal distension high atresia epigastric distension, visible gastric type, after severe vomiting distension disappeared, low atresia is manifested in the whole abdominal distension, intestinal sounds hyperactive, or visible intestinal type. 3, defecation condition After birth, the child does not excrete meconium or only excrete a small amount of gray-green mucus-like material, high intestinal atresia children after repeated vomiting, soon appear dehydration, electrolyte disorders and acidosis, low intestinal atresia in the late stage due to extreme enlargement of the intestinal canal, can be accompanied by perforation caused by peritonitis. In addition to the above clinical manifestations, high intestinal atresia can be seen as several fluid planes in the upper abdomen and no air in other intestinal cavities on the abdominal X-ray, while low intestinal atresia can be seen as most enlarged intestinal curves with fluid planes. Barium enema can be seen fetal type colon, characterized by small intestinal lumen, inconspicuous intestinal pouch-like folds, straighter and shorter intestine. IV. Treatment After the diagnosis of intestinal atresia is confirmed, surgical treatment should be performed immediately after correction of water and electrolyte disorders and acid-base imbalance. In case of membrane atresia, septal resection should be done; in case of blind segment atresia, end-to-end anastomosis should be done, and the enlarged hypertrophic intestine with poor blood supply at the proximal end of atresia should be removed during surgery to prevent postoperative anastomotic passage obstruction. Colonic atresia is often preceded by colostomy and second stage intestinal anastomosis, or first stage anastomosis. The higher the position of atresia, the better the prognosis. Early diagnosis and early treatment can improve the cure rate, otherwise, they die within a week, secondary to perforation, peritonitis, intestinal necrosis, aspiration pneumonia, etc. The mortality rate is as high as 40% because they are often premature and accompanied by other more serious malformations.