Pregnancy with excessive amniotic fluid and abnormal fetal movement should be taken seriously enough, and prenatal ultrasound examination can usually indicate suspicious lesions. With reference to the results of prenatal ultrasonography and the obvious surgical signs after birth, combined with the typical symptoms of vomiting, inability to feed, abdominal distention and absence of normal fetal stool, the diagnosis can mostly be made with the necessary auxiliary examinations such as abdominal plain film, abdominal ultrasonography and gastrointestinal imaging. Other diseases with typical symptoms similar to congenital intestinal atresia are relatively rare, and should be distinguished from functional abdominal distention and vomiting in internal medicine, etc. In addition, abdominal distention and vomiting caused by some genetic metabolic diseases also need to be concerned. In addition, abdominal distension and vomiting caused by some inherited metabolic diseases also need to be distinguished. Complete and mechanical intestinal obstruction due to various causes such as congenital total colon and congenital intestinal stenosis can also cause clinical manifestations similar to this disease and need to be distinguished.