The solutions for stubborn constipation are medication and lifestyle modifications. Commonly used medications for persistent constipation are laxatives, prokinetic agents, and probiotics. Laxatives include wheat cellulose, lactulose, polyethylene glycol, and cialis. Prokinetic drugs include mosapride and domperidone. Probiotics are Bifidobacterium bifidum, Lactobacillus acidophilus, etc. Lifestyle adjustment is the basis of treatment, in general, drink more water, eat more vegetables and fruits rich in dietary fiber, such as broccoli, radish, apple, banana and so on. Do more exercise, which can increase the activity of intestinal muscles. Pay attention to mood regulation and avoid excessive stress. But be careful, you must use medication under the guidance of a doctor, do not self-medicate.