Many of you are likely to drink alcohol, even heavily, before or during the rabies vaccination. So “can I drink alcohol for rabies vaccination? First, drinking alcohol 12 hours before the rabies vaccination has little effect on the vaccination. After a person drinks, alcohol is absorbed by the stomach and intestinal walls, dissolved in the blood, and circulated in the body and metabolized in the body. The effect of alcohol on the human body depends on the concentration of alcohol in the human blood, and the concentration is not only related to the amount of alcohol consumed, but also to the speed of alcohol decomposition in the human body. More than 90% of the alcohol in the human body is oxidized and decomposed by the liver, so the strength of the human liver’s ability to decompose alcohol determines the speed of the body’s decomposition of alcohol. Fast people, the liver can quickly break down alcohol in the body within five hours, and can reduce the concentration of alcohol in the blood to a lower level. In slow people, the blood alcohol concentration in the body will still be high in the same amount of alcohol consumed and in the same amount of time. Usually most people can complete the metabolism of alcohol within 12 hours, so drinking 12 hours before the rabies vaccination will have little effect on the vaccination. Second, drinking alcohol during rabies vaccination will have some effect on the effect of the vaccine and can also cause adverse reactions to the vaccine, such as fever, redness and hardness, and anaphylaxis. 1. Alcohol is a stimulating beverage that causes vasodilation and has a certain stimulating effect on the wound, which can cause difficulty in wound healing and increase the risk of wound exposure, and alcohol can accelerate the speed of rabies virus nerve movement and shorten the incubation period, resulting in a significant reduction in the antibody effect of the vaccine. 2. Alcohol enters the human body as ethanol cannot be digested and absorbed, and will enter the brain with the blood. In the brain, ethanol will destroy the neuronal cell membrane and will indiscriminately bind to many neuronal receptors. Alcohol weakens the central nervous system and causes retardation of brain activity by activating inhibitory neurons (gamma-aminobutyric acid) and inhibiting activating neurons (glutamate, nicotine). In the human body, there is a neuro-endocrine-immune regulatory system, and the three systems interact with each other. Alcohol acts on the nervous system and vaccine acts on the immune system, while a large amount of alcohol abuse causing physical discomfort may affect the immune system, thus affecting the effect after vaccination. 3. Vaccines are autoimmune preparations for the prevention of infectious diseases made from pathogenic microorganisms (such as bacteria, rickettsiae, viruses, etc.) and their metabolites, which are artificially attenuated, inactivated or made by using genetic modification. Alcohol may cause some damage to the components of the vaccine. If the components of the vaccine are damaged, the nature of the vaccine will be changed and symptoms such as fever, redness, swelling and hard nodules may occur in mild cases, and even anaphylactic shock may occur in severe cases. In summary, drinking alcohol 12 hours before the rabies vaccination has little effect on the vaccine. It is recommended that you do not drink alcohol, strong tea, chili, onion and garlic stimulating foods and strenuous exercise during the vaccination, and do not take a shower on the day of the injection. In case of heavy drinking, major diseases and other problems that may affect the immune system during the vaccination, people with congenital or acquired immunodeficiency, or people who are using immunosuppressive drugs, if you are not sure about the effect of the vaccine, you can go to a qualified institution to test whether rabies antibodies are produced half a month after the full rabies vaccination, and if the vaccine is not effective, you can continue to receive a rabies vaccine booster. If the vaccine is not effective, you can continue to receive a booster shot.