Prostate injection therapy is a method of injecting selected antibiotics directly into the prostate tissue via the suprapubic, perineum or rectum to achieve better results. Clinically, chronic prostatitis and other diseases, due to the prostate membrane blocking the role of drugs, oral or intravenous injection of drugs is not effective; injection therapy directly penetrate the membrane, deep tissue, can be a short period of time will be a higher concentration of drugs in the focal point of the tissue to improve the therapeutic effect. Generally, injection is given 1 to 2 times a week, and a course of treatment does not exceed 10 times. The main precautions of this therapy are: 1. The operator must be familiar with the anatomical knowledge of the prostate, accurately understand its location and structure, if necessary, combined with ultrasound-guided injection to ensure accuracy. 2. Antibiotic selection, mainly based on prostate fluid bacterial culture and drug sensitivity test, individualized and targeted treatment, without considering pharmacokinetics. 3. The choice of injection route, mainly suprapubic area, perineum, rectal wall, etc.; the rectal wall is easy to be infected, perineum injection may appear hematuria, etc., each has its own advantages and disadvantages. Prostate injection therapy has a certain risk, must be carried out in a regular hospital by a professional physician, accidents occur in a timely manner.