Acute cholecystitis may cause elevated transaminases. Aminotransferases, including alanine aminotransferase and glutamic aminotransferase, are important indicators of liver function. Elevated alanine aminotransferase can be seen in viral hepatitis, cirrhosis of the liver, and drug-induced hepatitis, while elevated glutamic aminotransferase can be seen in viral hepatitis, hepatocellular carcinoma, acute myocardial infarction, muscular dystrophy, and other diseases. Infection-induced cholecystitis can spread to the liver when the infection is not well controlled, which may lead to impaired liver function, and after the liver function is impaired, the transaminases in the hepatocytes can be released into the blood, leading to the elevation of serum transaminases; in the case of cholecystitis combined with gallbladder stones, when the stones are located in the neck of the gallbladder, the contraction of the gallbladder can cause the obstruction of the common bile duct and the bile ducts above the common bile duct, which will then lead to the elevation of transaminases. Therefore, acute cholecystitis may cause transaminase elevation, and it is recommended to go to the hospital for consultation when the transaminase value is abnormal.