Vacuoles in lung nodules are not necessarily malignant. The presence of vacuoles in lung nodules is usually a hint of chest CT examination, such as lung nodules and masses, which may have vacuoles within the lesions. However, not only malignant diseases such as lung cancer and metastatic lung cancer may have the sign of lung vacuoles, but also benign lesions such as tuberculomas and inflammatory pseudotumors of the lung may have the sign of lung vacuoles. Therefore, vacuoles in lung nodules are not necessarily malignant lesions, but may also be benign lesions. If there are vacuoles in lung nodules, there is no need to worry too much, it is recommended to cooperate with professional respiratory physician to improve the follow-up examination as soon as possible, such as chest enhancement CT, lung puncture biopsy, bronchoscopy, etc., to clarify the specific type of disease, the nature of the nodule, etc., the professional doctor to assess and analyze the disease and diagnosis, to rule out the possibility of malignant pathology in a timely manner, and to formulate a targeted treatment plan.