Metronidazole for toothache is usually paired with cephalosporin or penicillin antibiotics such as cefixime and amoxicillin. However, not all toothaches can be treated with medication, and patients should seek medical examination and receive dental treatment or oral antimicrobial medication, depending on the situation. Metronidazole is mainly a drug for anaerobic infections, and infections in the oral cavity can include a combination of anaerobic and aerobic bacteria, so when periodontitis, wisdom tooth pericoronitis, gingivitis occurs, it can be treated locally with the use of a combination of the two types of antibiotics for adjuvant treatment. Patients with allergies to cephalosporins can choose roxithromycin or azithromycin. If the toothache is caused by caries, pulpitis, wedge-shaped defects, cryptic cracks, etc., the use of metronidazole has no therapeutic effect, and it is necessary for the doctor to carry out fillings, root canal treatment, etc. according to the different circumstances in order to eradicate the toothache. If you have a toothache, you should consult a doctor who will choose a treatment plan according to your condition. The above medications should be used in accordance with your doctor’s instructions.