Pain in the middle of the chest may be caused by coronary heart disease, gastric ulcer, pleurisy and other factors. 1. Coronary heart disease: the typical manifestation of coronary heart disease is the left anterior chest or sternal back pain, which can be manifested as a sense of pressure, squeezing, etc., generally because of coronary atherosclerosis caused by myocardial ischemia. 2. Gastric ulcer: the stomach is usually located below the heart, if there is an open ulcer on the inner wall of the stomach, it may lead to abdominal burning pain, abdominal distension, acid reflux and other symptoms. 3. Pleurisy: If inflammation occurs in the pleural tissues, it may lead to symptoms of chest pain, which is usually manifested as a sudden stabbing pain, and deep breathing and coughing may lead to aggravation of the pain. In addition, trauma, intercostal neuritis, gastritis, gastric cancer and other diseases may also lead to pain in the middle of the chest, when this symptom occurs and persists unrelieved, it is recommended that the patient consult the doctor in time to improve the relevant examination, so as to avoid delaying the condition.