Autologous fat fillers are not obviously harmful, but some abnormalities can occur. Taking facial fat filler as an example, filling fat in different structural levels can make the removal of fat more difficult due to the complex facial tissue structure with the presence of facial nerves, muscles and other important structures. Incorrect methods of fat filling are likely to produce problems such as overfilling, unevenness, and fat displacement, which are difficult to remove. When the injection is shallow, small nodules may be felt in the fat-filled area, so it is necessary to find an experienced professional for fat injection filling. In addition, the biggest problem of fat filler is the survival rate. Generally, it may take 2-3 fillings to get good results and to establish a new blood supply system for the fat to survive after the fat transfer. In most cases, fat grafting of the same area can be performed again after 3 months or more. Autologous fat has the advantages of easy to take, abundant source, easy operation, realistic and natural, and more importantly, no foreign body rejection and adverse effects. Facial fat filler is site-specific, and the anatomical characteristics of each part must be taken into consideration, and the indications must be strictly grasped for correct filling in order to avoid adverse consequences.