The International Health Organization (WHO) states that “desensitization is the only possible cure for allergic diseases” and officially recommends the effectiveness and safety of specific immunotherapy (desensitization). Allergen injection desensitization therapy is the intradermal injection of allergen extracts. Desensitization injections are started at small doses and gradually increased to increase tolerance to the allergen. Injectable desensitization therapy usually takes at least 2 to 3 years, and long-term injections can be painful. Sublingual desensitization therapy Sublingual desensitization therapy involves making desensitizing solutions of different concentrations of allergy-inducing substances (such as dust mite active protein) and administering them daily in small doses that the patient can adapt to (placing the desensitizing drops under the tongue, allowing them to be absorbed slowly and swallowed after 1 to 3 minutes), gradually increasing the dose to reach a maintenance level and then continuing for a sufficient time to improve the patient’s tolerance. Sublingual desensitization, sublingual desensitization therapy is the use of extracts of allergens dropped under the tongue to produce tolerance in the respiratory mucosa, thereby reducing or controlling allergy symptoms and achieving the goal of desensitization therapy. The disadvantage is that it is only effective for dust mite allergy. Nano desensitization therapy Modern medicine believes that most allergic diseases are type I allergic reactions of the upper respiratory mucosa to allergens such as inhaled dust, insect eggs, house dust and cold air. Nano desensitization therapy, changing the route of drug delivery, penetrating into the body through the skin. wk-2001 type desensitization paste in the package of a variety of allergens dry powder, and add Tio2 (titanium dioxide) nanocrystals and with far infrared gasket. tio2 (titanium dioxide) nanocrystals in the light and far infrared catalyst, can effectively decompose the organic matter in the allergen dry powder, producing free small molecules of antigen; at the same time, the Tio2 (titanium dioxide) nano-microcrystals under the light catalysis and can decompose the hair skin keratin layer protein, so that the epithelial tissue gap increases, which is conducive to promoting small molecule antigen continuous and maximum penetration of skin into the body. The body in the long-term continuous stimulation of these antigens gradually produce immune tolerance, no reaction to re-exposure to allergens, to achieve the purpose of complete desensitization of the body. Non-specific treatment 1. Antihistamines: The first generation of antihistamines such as paracetamol, diphenhydramine and Omnicare are gradually abandoned in clinical practice due to side effects such as drowsiness. In recent years, the common features of the second generation antihistamines are no drowsiness, drowsiness and other side effects, and the duration of action is up to 24 hours, such as cetirizine, loratadine, azelastine, ketotifen, terfenadine and astemizole, etc. Due to the serious cardiotoxic side effects of terfenadine and astemizole, they are rarely used, and ketotifen is less used due to drowsiness. The main drugs commonly used in China are cetirizine, loratadine, epalrestine, etc. The third-generation antihistamines include fexofenadine, levocetirizine, efletirizine, desloratadine, etc. The third-generation antihistamines have neither CNS depressant effects nor cardiotoxic side effects and can Better control the symptoms of allergic rhinitis, and have a role in the prevention of asthma. 2.Glucocorticoid inhalation: Budesonide, fluticasone, mometasone furoate, etc. are usually used. The use of glucocorticoid aerosol for asthma with oral and nasal storage fog cans for nasal inhalation can achieve better results than the above drugs, this inhalation method does not have the irritation of the nasal mucosa, but can also comprehensively control nasal inflammation and prevent recurrence, more importantly, it can simultaneously prevent and control the airway inflammation of asthma, which is the preferred mode of administration for allergic rhinitis and has achieved good results in the clinic. 3.Mast cell membrane stabilizers include sodium cromoglycate (SCG): Nedocromil Sodium and Tranilast, etc. 4, the application of local antihistamines: mainly azelastine, levocabastine and ketotifen, etc.