Long-term vaginal drug insertion may produce side effects such as destroying the vaginal environment and producing drug resistance. 1. Destruction of the vaginal environment: due to the presence of normal vaginal flora such as Lactobacillus vaginalis and Escherichia coli and other pathogenic bacteria, long-term vaginal drug may destroy Lactobacillus vaginalis or make the local pH value changes, which can easily lead to the reproduction of other pathogenic bacteria and the occurrence of vaginitis. 2. Produce drug resistance: for vaginitis patients, if the long-term use of nifurtimox, bisacodyl suppositories and other preparations, it is easy to lead to local pathogenic bacteria to produce drug resistance, when vaginitis reoccurs, the therapeutic effect of the use of these drugs is greatly reduced or even ineffective. For patients who need vaginal plugs, they should be used under the guidance of a doctor, and should not be used blindly to avoid the above side effects.