Based on relevant clinical evidence, cases of simple infections with Salmonella typhi usually show clinical improvement within 3-5 days if treated successfully. Most clinical trials show an average time to fever reduction of 4-6 days. However, the time to cure the disease varies from person to person and should not be generalized. Even so, enteric fever can recur in immunocompetent individuals after clinical cure, when the recurrence usually occurs 2-3 weeks after the fever has subsided. The risk of recurrence depends on the antibiotic used to treat the initial infection. The recurrence rate with the bacteriostatic agent chloramphenicol used to be 10-25%, but later studies incorporating multidrug-resistant Salmonella typhimurium infections and newer antibiotics have found a lower recurrence rate of 1-6%. There are various treatments available for the disease, so the exact time to cure cannot be generalized, but should be determined in the context of the patient’s specific condition and the presence or absence of other co-morbidities. Once the symptoms associated with the infection appear, such as fever, abdominal pain, etc., it is recommended to actively go to the Department of Infectious Diseases for treatment, and antibiotics can be used, such as moxifloxacin, cefoperazone sodium/sulbactam sodium. Specific medication is under the guidance of a specialist.