Symptoms of lymphoma cancer spreading are mainly manifested as persistent high fever, and different symptoms exist in different parts of the body where it spreads. For example, spreading mediastinum, hilar lymph nodes, spreading to mesentery, peritoneal lymph nodes, spreading to liver and so on. 1. Persistent high fever: lymphoma patients with spreading cancer cells often have persistent high fever symptoms, and it is difficult to be controlled by applying drugs. 2. Spreading to mediastinal and hilar lymph nodes: after the cancer cells of lymphoma patients spread to mediastinal and hilar lymph nodes, they may form large lumps locally, which may cause the patients to suffer from chest pain, chest tightness and other uncomfortable symptoms. 3. Spreading to mesenteric and peritoneal lymph nodes: when cancer cells of lymphoma patients spread to mesenteric and peritoneal lymph nodes, large lumps may be formed locally, which may lead to abdominal lumps with abdominal pain, and in serious cases, intestinal obstruction, ureteral obstruction and other symptoms may occur. 4. Spreading to liver: after the cancer cells of lymphoma patients spread to liver, patients will have symptoms of enlarged liver and jaundice. When lymphoma is diagnosed, patients should actively cooperate with doctors to carry out treatment and conditioning, try to control the disease and slow down its progress.