There is no serious perioral dermatitis how to treat the fastest this kind of statement, perioral dermatitis patients can take general treatment, medication, etc., so as to alleviate the symptoms of the disease. 1. General treatment: long-term use of glucocorticoid drugs or fluoride toothpaste caused by perioral dermatitis, need to stop the use of fluoride toothpaste, or gradually reduce the use of drugs, lesions can gradually subside. 2. medication: patients with perioral dermatitis can use antibiotic drugs under the guidance of the doctor, such as erythromycin, metronidazole, clindamycin and so on. Simply external drugs can not relieve the disease, patients can follow the doctor’s instructions oral antibiotic drugs, such as minocycline, doxycycline, etc.. After standardized drug treatment, the symptoms can be improved. It is recommended that patients with perioral dermatitis actively cooperate with doctors to take relevant treatment measures.