A lump of flesh on the leg is mostly caused by sebaceous cysts, enlarged lymph nodes and sarcoma. 1. Sebaceous cysts: due to the sebaceous glands in the skin of the legs, the sebaceous cysts are formed after the sebum accumulation, which are mostly solitary and usually have no obvious symptoms. 2. Enlarged lymph nodes: mostly caused by bacterial infection, parasites, tuberculosis, lymph node or tumor metastasis. 3. Sarcoma: it belongs to a kind of malignant tumor, which occurs in the skin, subcutaneous, periosteum or the ends of long bones, and may present local pain and swelling symptoms. If you have meat bumps on your legs, you need to go to the hospital in time for relevant examination, find out the cause of the disease, and cooperate with the doctor to carry out targeted treatment.